Advancements in Biological Dosimetry Techniques for Surge Response to Radiation Emergencies in Ghana
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Abstract
Abstract
The awareness of the use of biodosimetry to estimate external radiation doses received by individuals and in radiation oncology, nuclear medicine, diagnostic, and interventional radiology has gained traction in recent years. At present Ghana is poised to integrate about 1GW of nuclear power into its electricity mix by 2034. The increased awareness of biodosimetry is probably due to increased radiological threats and incidents, medical and forensic applications, the quest to strengthen emergency response to unplanned radiation exposures such as radiological accidents, and the malevolent use of radioactive sources. Biodosimetry capabilities would play an effective role during public health management of radiation emergencies for rapid dose estimation and help to medically categorize the exposures for the purpose of prioritizing treatment of the affected persons. Moreover, it will also serve to provide reassurance and psychological support for the “worried-well”. Biodosimetry methods and infrastructure can also be utilized for various applications, including molecular research, medical cytogenetics, and forensics.
This write-up assesses the status of biodosimetry methods and infrastructure capabilities available at the Ghana Atomic Energy Commission (GAEC), which could be leveraged during radiological or allied scenarios.
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International Atomic Energy Agency. Nuclear Technology Review 2015. Vienna: IAEA; 2015. Available from: https://www.iaea.org/sites/default/files/ntr2015.pdf
Rich SE, Dharmarajan KV. Introduction to radiation therapy. In: Essentials of Interv Cancer Pain Manag. 2018;319-328. Available from: https://doi.org/10.1007/978-3-319-99684-4_36
FBI. East African Embassy Bombings. 2024. Available from: https://www.fbi.gov/history/famous-cases/east-african-embassy-bombings
Schaefer TM. When terrorism hits home: Domestic newspaper coverage of the 1998 and 2002 terror attacks in Kenya. Stud Conflict Terror. 2006;29(6):577-589. Available from: https://doi.org/10.1080/10576100600803523
Shinn DH. Terrorism in East Africa and the Horn: An overview. J Confl Stud. 2003;23(2):79-91. Available from: https://id.erudit.org/iderudit/jcs23_2art05
Debrah SK, Nyasapoh MA, Ameyaw F, Yamoah S, Allotey NK, Agyeman F. Drivers for nuclear energy inclusion in Ghana’s energy mix. J Energy. 2020;1-12. Available from: https://doi.org/10.1155/2020/8873058
GNA. President Akufo-Addo approves nuclear technology in Ghana’s energy mix. 2022. Available from: https://gna.org.gh/2022/08/president-akufo-addo-approves-nuclear-technology-in-ghanas-energy-mix/#google_vignette
Gyamfi K, Birikorang SA, Ampomah-Amoako E, Fletcher JJ, Osei B. The choice of nuclear energy for Ghana as a result of development of its energy production. J Energy. 2020;1-6. Available from: https://doi.org/10.1155/2020/8823720
International Atomic Energy Agency. Safety Reassessment for Research Reactors in the Light of the Accident at the Fukushima Daiichi Nuclear Power Plant. 2014. Available from: http://www-pub.iaea.org/MTCD/Publications/PDF/Pub1615_web.pdf
Ainsbury E, Badie C, Barnard S, Manning G, Moquet J, Abend M, et al. Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans – joint RENEB and EURADOS inter-laboratory comparisons. Int J Radiat Biol. 2017;93(1):99-109. Available from: https://doi.org/10.1080/09553002.2016.1206233
Ainsbury EA, Bakhanova E, Barquinero JF, Brai M, Chumak V, Correcher V, et al. Review of retrospective dosimetry techniques for external ionising radiation exposures. Radiat Prot Dosimetry. 2011;147(4):573-592. Available from: https://doi.org/10.1093/rpd/ncq499
International Commission on Radiation Units and Measurements (ICRU). ICRU Report 94: Methods for Initial-Phase Assessment of Individual Doses Following Acute Exposure to Ionizing Radiation. J ICRU. 2019;19(1). Available from: https://www.icru.org/report/icru-report-94-methods-for-initial-phase-assessment-of-individual-doses-following-acute-exposures-to-ionizing-radiation/
Liu Q, Cao J, Wang ZQ, Bai YS, Lü YM, Huang QL, Zhao WZ, et al. Dose estimation by chromosome aberration analysis and micronucleus assays in victims accidentally exposed to (60)Co radiation. Br J Radiol. 2009;82(984):1027-1032. Available from: https://doi.org/10.1259/bjr/62484075
IAEA. IAEA Biological Dosimetry Model Laboratory Receives Equipment via Public-Private Partnership. 2020. Available from: https://www.iaea.org/newscenter/news/iaea-biological-dosimetry-model-laboratory-receives-equipment-via-public-private-partnership
World Health Organization. International Health Regulations. Geneva: WHO; 2005. Available from: http://apps.who.int/iris/bitstream/10665/43883/1/9789241580410_eng.pdf.
Escalona MB, Ryan TL, Balajee AS. Current developments in biodosimetry tools for radiological/nuclear mass casualty incidents. Environ Adv. 2022;9:100265. Available from: https://doi.org/10.1016/j.envadv.2022.100265
IAEA. Cytogenetic Dosimetry: Applications in Preparedness for and Response to Radiation Emergencies. 2011. Available from: https://www-pub.iaea.org/mtcd/publications/pdf/epr-biodosimetry%202011_web.pdf
Kulka U, et al. Realising the European Network of Biodosimetry (RENEB). Radiat Prot Dosim. 2012;151(4):621–625. Available from: https://doi.org/10.1093/rpd/ncs157
Wilkins RC, Lloyd DC, Maznyk NA, Carr Z. The international biodosimetry capacity, capabilities, needs and challenges: The 3rd WHO BioDoseNet survey results. Environ Adv. 2022;8. Available from: https://doi.org/10.1016/j.envadv.2022.100202
Wilkins RC, Carr Z, Lloyd DC. An update of the WHO BioDoseNet: Developments since inception. Radiat Prot Dosim. 2016;1-11. Available from: https://doi.org/10.1093/rpd/ncw154
Agbenyegah S. Radiological and Medical Sciences Research Institute, Ghana Atomic Energy Commission [Personal Communication]. 2024. Available from: https://ramsri.gaec.gov.gh/
IAEA. Cytogenetic Analysis for Radiation Dose Assessment: A Manual. 2001. Available from: http://www-pub.iaea.org/MTCD/publications/PDF/TRS405_scr.pdf
Achel DG, Achoribo E, Agbenyegah S, Adaboro RM, Donkor S, Adu-Bobi NAK, et al. Towards establishing capacity for biological dosimetry at Ghana Atomic Energy Commission. Genome Integr. 2016;7(1). Available from: https://doi.org/10.4103/2041-9414.197173
Owusu J. Cytogenetic monitoring of radiation exposure in diagnostic and interventional radiology workers in Ghana. A thesis submitted to the University of Ghana, Legon in partial fulfillment of the Award of a MPhil Degree in Health Physics and Radiation Protection. 2023.
Rothkamm K, Lobrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses. Proc Natl Acad Sci U S A. 2003;100:5057–5062. Available from: https://doi.org/10.1073/pnas.0830918100
Zhu J, Ma X, Zhang Y, Ni D, Ai Q, Li H, Zhang X. Establishment of a miRNA-mRNA regulatory network in metastatic renal cell carcinoma and screening of potential therapeutic targets. Tumor Biol. 2016;37(12):15649–15663. Available from: https://doi.org/10.1007/s13277-016-5135-6
Fenech M. The cytokinesis-block micronucleus technique and its application to genotoxicity studies in human populations. Environ Health Perspect. 1993;101 Suppl 3:101-107. Available from: https://doi.org/10.1289/ehp.93101s3101
Rothkamm K, Beinke C, Romm H, Badie C, Balagurunathan Y, Barnard S, et al. Comparison of established and emerging biodosimetry assays. Radiat Res. 2013;180(2):111–119. Available from: https://doi.org/10.1667/RR3231.1
Achel DG, Serafin AM, Akudugu JM. Flow cytometry-assisted quantification of γH2AX expression has potential as a rapid high-throughput biodosimetry tool. Radiat Environ Biophys. 2016. Available from: https://doi.org/10.1007/s00411-016-0654-5
Paul S, Amundson SA. Development of gene expression signatures for practical radiation biodosimetry. Int J Radiat Oncol Biol Phys. 2008;71(4):1236-1244. Available from: https://doi.org/10.1016/j.ijrobp.2008.03.043
Port M, Herodin F, Valente M, Drouet M, Lamkowski A, Majewski M, et al. First generation gene expression signature for early prediction of late occurring hematological acute radiation syndrome in baboons. Radiat Res. 2016;186(1):39-54. Available from: http://www.jstor.org/stable/44028614
Agbenyegah S, Abend M, Atkinson MJ, Combs SE, Trott KR, Port M, Majewski M. Impact of Inter-individual Variance in the expression of a Radiation Responsive Gene panel Used for Triage. Radiat Res. 2018;190:226-235. Available from: https://doi.org/10.1667/rr15013.1
Agbenyegah S. Defining Baseline of Gene expression on healthy human donors. A dissertation presented to the School of Medicine, Technical University of Munich (TUM) in partial fulfilment for the award of an MSc degree in Radiation Biology. 2017.
GmbH Q, GmbH P. QIAsymphony® PAXgene® Blood RNA Kit Handbook. 2016. Available from: www.preanalytix.com
Pantelias GE, Maillie HD. A simple method for premature chromosome condensation induction in primary human and rodent cells using polyethylene glycol. Somatic Cell Genet. 1983;9:533-547. Available from: https://link.springer.com/article/10.1007/BF01574257
Pantelias A, Terzoudi GI. Development of an automatable micro-PCC biodosimetry assay for rapid individualized risk assessment in large-scale radiological emergencies. Mutat Res Genet Toxicol Environ Mutagen. 2018;836:65-71. Available from: https://doi.org/10.1016%2Fj.mrgentox.2018.05.013
Terzoudi GI, Pantelias G, Darroudi F, Barszczewska K, Buraczewska I, Depuydt J, et al. Dose assessment intercomparisons within the RENEB network using G0-lymphocytes prematurely condensed chromosomes (PCC assay). Int J Radiat Biol. 2017;93:48-57. Available from: https://doi.org/10.1080%2F09553002.2016.1234725
Yadav U, Bhat NN, Shirsaath KB, Mungse US, Sapra BK. Refined premature chromosome condensation (G0 PCC) with cryo preserved mitotic cells for rapid radiation biodosimetry. Sci Rep. 2021;11:13498. Available from: https://doi.org/10.1038/s41598-021-92886-6
Chambrette V, Laval F, Voisin P. The utility of lymphocyte premature chromosome condensation analysis for biological dosimetry following accidental overexposure to ionizing radiation. Radiat Prot Dosimetry. 1999;82:125–131.
Blakely WF, Prasanna PG, Kolanko CJ, Pyle MD, Mosbrook DM, Loats AS, et al. Application of the premature chromosome condensation assay in simulated partial-body radiation exposures: Evaluation of the use of an automated metaphase-finder. Stem Cells. 1995;13(Suppl 1):223-230. Available from: https://pubmed.ncbi.nlm.nih.gov/7488950/
Blakely WF, Salter CA, Prasanna PGS. Early-response biological dosimetry--recommended countermeasure enhancements for mass-casualty radiological incidents and terrorism. Health Phys. 2005;89(5):494-504. Available from: http://www.ncbi.nlm.nih.gov/pubmed/16217193
Ji Y, Karbaschi M, Abdulwahed A, Quinete NS, Evans MD, Cooke MSA. High-throughput comet assay approach for assessing cellular DNA damage. J Vis Exp. 2022;18. Available from: https://doi.org/10.3791/63559
Hladik D, Bucher M, Endesfelder D, Oestreicher U. The potential of omics in biological dosimetry. Radiation. 2022;2:78–90. Available from: https://doi.org/10.3390/radiation2010006
Choueiry F, Singh S, Sircar A, Laliotis G, Sun X, Chavdoula E, et al. Integration of metabolomics and gene expression profiling elucidates IL4I1 as modulator of ibrutinib resistance in ABC-diffuse large B cell lymphoma. Cancers (Basel). 2021 Apr 29;13(9):2146. Available from: https://doi.org/10.3390/cancers13092146
Satyamitra MM, Cassatt DR, Hollingsworth BA, Price PW, Rios CI, Taliaferro LP, et al. Metabolomics in radiation biodosimetry: Current approaches and advances. Metabolites. 2020 Aug 11;10(8):328. Available from: https://doi.org/10.3390/metabo10080328
Greenstock CL, Trivedi A. Biological and biophysical techniques to assess radiation exposure: A perspective. Prog Biophys Mol Biol. 1994;61:81-130. Available from: https://doi.org/10.1016/0079-6107(94)90007-8
Swartz HM, Flood AB, Gougelet RM, Rea ME, Nicolalde RJ, Williams BA. Critical assessment of biodosimetry methods for large-scale incidents. Health Phys. 2010;98(2):95-108. Available from: https://doi.org/10.1097/HP.0b013e3181b8cffd
DeWitt R, Klein DM, Yukihara EG, Simon SL, McKeever SWS. OSL and tooth enamel and its potential use in post-exposure triage. Health Phys. 2010;98:000-000. Available from: https://doi.org/10.1097/01.hp.0000347997.57654.17
Swartz HM, Williams BB, Nicolalde RJ, Demidenko E, Flood AB. Overview of biodosimetry for management of unplanned exposures to ionizing radiation. Radiat Meas. 2011;46(9):742-748. Available from: https://doi.org/10.1016/j.radmeas.2011.03.011
Wojcik A, Lloyd D, Romm H, Roy L. Biological dosimetry for triage of casualties in a large-scale radiological emergency: capacity of the EU member states. Radiat Prot Dosim. 2009;138(4):397–401. Available from: https://doi.org/10.1093/rpd/ncp279
Ghana and China to cooperate on HPR 1000 Nuclear project. 2024. Available from: https://gaec.gov.gh/ghana-and-china-to-co-operate-on-hpr-1000-nuclear-project/
US and Ghana Advance Cooperation on clean secure safe and reliable nuclear energy. 2024. Available from: https://gh.usembassy.gov/u-s-and-ghana-advance-cooperation-on-clean-secure-safe-and-reliable-nuclear-energy/#:~:text=Today's%20announcements%20build%20on%20the,support%20future%20SMR%20supply%20chain
US and Ghana Nuclear firms sign landmark commercial agreements for small modular reactor projects in Ghana. 2024. Available from: https://www.state.gov/u-s-and-ghana-nuclear-firms-sign-landmark-commercial-agreement-for-small-modular-reactor-project-in-ghana/.
Kulka U, Wojcik A, Di Giorgio M, Wilkins R, Suto Y, Jang S, et al. Biodosimetry and biodosimetry networks for managing radiation emergencies. Radiat Prot Dosim. 2018 Dec 1;182(1):128-138. Available from: https://doi.org/10.1093/rpd/ncy137
Swartz HM, Wilkins RC, Ainsbury E, Port M, Flood AB, Trompier F, et al. What if a major radiation incident happened during a pandemic? – Considerations of the impact on biodosimetry. Int J Radiat Biol. 2022;98(5):825-830. Available from: https://doi.org/10.1080/09553002.2021.2000659