Improving Cytogenetic Surveillance in Radiology Workers Exposed to Low-Dose Radiation in Africa: A Call to Action

Main Article Content

Daniel G Achel
Agbenyegah Sandra
James Owusu

Abstract

Abstract


Radiation exposure is an occupational hazard for diagnostic and interventional radiology workers, potentially leading to chromosomal damage and increased cancer risk. This review explores the status of cytogenetic monitoring of radiation exposure among radiology workers in Africa. Monitoring of Radiation Exposure in Diagnostic and Interventional Radiology Workers in Ghana and Africa provides a crucial examination of radiation safety practices within the Ghanaian and Africa healthcare sector. We recovered existing literature on the cytogenetic surveillance conducted on radiology workers in Ghana and Africa stressing on the impact and/or significance of cytogenetic monitoring programmes. In these studies, mostly mathematical modeling and physical methods were used to estimate and extrapolate risks of exposure to ionizing radiation. Additionally, we discuss the challenges and opportunities for implementing cytogenetic monitoring programmes in Africa particularly Ghana and provide recommendations for future research and occupational health policies.


This review attempts to bridge the gap between physical and biological dosimetry in surveillance studies. It addresses the significant gap in cytogenetic monitoring among diagnostic and interventional radiology workers in Africa. It highlights the importance of cytogenetic surveillance for early detection of radiation-induced genetic damage, assesses the current practices, and provides a recommendation and a roadmap for establishing robust monitoring programmes. This work would contribute significantly to the understanding of occupational radiation safety issues in the healthcare sector of Africa. It also offers a comprehensive examination of the challenges and opportunities in implementing cytogenetic monitoring programmes.

Downloads

Download data is not yet available.

Article Details

Daniel G Achel, Agbenyegah Sandra, & James Owusu. (2024). Improving Cytogenetic Surveillance in Radiology Workers Exposed to Low-Dose Radiation in Africa: A Call to Action. Archives of Applied Biology, 001–006. https://doi.org/10.17352/aab.000001
Articles

Copyright (c) 2024 Achel DG, et al.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Licensing and protecting the author rights is the central aim and core of the publishing business. Peertechz dedicates itself in making it easier for people to share and build upon the work of others while maintaining consistency with the rules of copyright. Peertechz licensing terms are formulated to facilitate reuse of the manuscripts published in journals to take maximum advantage of Open Access publication and for the purpose of disseminating knowledge.

We support 'libre' open access, which defines Open Access in true terms as free of charge online access along with usage rights. The usage rights are granted through the use of specific Creative Commons license.

Peertechz accomplice with- [CC BY 4.0]

Explanation

'CC' stands for Creative Commons license. 'BY' symbolizes that users have provided attribution to the creator that the published manuscripts can be used or shared. This license allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author.

Please take in notification that Creative Commons user licenses are non-revocable. We recommend authors to check if their funding body requires a specific license.

With this license, the authors are allowed that after publishing with Peertechz, they can share their research by posting a free draft copy of their article to any repository or website.
'CC BY' license observance:

License Name

Permission to read and download

Permission to display in a repository

Permission to translate

Commercial uses of manuscript

CC BY 4.0

Yes

Yes

Yes

Yes

The authors please note that Creative Commons license is focused on making creative works available for discovery and reuse. Creative Commons licenses provide an alternative to standard copyrights, allowing authors to specify ways that their works can be used without having to grant permission for each individual request. Others who want to reserve all of their rights under copyright law should not use CC licenses.

Baudin C, Bernier MO, Klokov D, Andreassi MG. Biomarkers of genotoxicity in medical workers exposed to low-dose ionizing radiation: Systematic review and meta-analyses. Int J Mol Sci. 2021 Jul 19;22(14):7504. Available from: https://doi.org/10.3390/ijms22147504.

Streffer C. International Commission on Radiological Protection. ICRP 2007 recommendations. Radiat Prot Dosimetry. 2007;127(1-4):2-7. Available from: https://doi.org/10.1093/rpd/ncm246.

United Nations Scientific Committee on the Effects of Atomic Radiation. Sources, effects and risks of ionizing radiation, United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 2016 Report: Report to the General Assembly, with Scientific Annexes. United Nations. 2017. Available from: https://www.unscear.org/docs/publications/2016/UNSCEAR_2016_GA-Report.pdf.

Little MP, Wakeford R, Bouffler S, Abalo K, Hauptmann M, Hamada N, et al. Cancer risks among studies of medical diagnostic radiation exposure in early life without quantitative estimates of dose. Sci Total Environ. 2022;832:154723. Available from: https://doi.org/10.1016/j.scitotenv.2022.154723.

Linet MS, Slovis TL, Miller DL, Kleinerman R, Lee C, Rajaraman P, et al. Cancer risks associated with external radiation from diagnostic imaging procedures. CA Cancer J Clin. 2012;62(2):75-100. Available from: https://doi.org/10.3322/caac.21132.

Xiao C, He N, Liu Y, Wang Y, Liu Q. Research progress on biodosimeters of ionizing radiation damage. Radiat Med Prot. 2020;1(3):127-132. Available from: https://doi.org/10.1016/j.radmp.2020.06.002.

Gerić M, Popić J, Gajski G, Garaj-Vrhovac V. Cytogenetic status of interventional radiology unit workers occupationally exposed to low-dose ionising radiation: A pilot study. Mutat Res. 2019;843:46-51. Available from: https://doi.org/10.1016/j.mrgentox.2018.10.001.

Bouraoui S, Mougou S, Drira A, Tabka F, Bouali N, Mrizek N, et al. A cytogenetic approach to the effects of low levels of ionizing radiation (IR) on the exposed Tunisian hospital workers. Int J Occup Med Environ Health. 2013;26:144-154. Available from: https://doi.org/10.2478/s13382-013-0084-4.

Doukali H, Ben Salah G, Ben Rhouma B, Hajjaji M, Jaouadi A, Belguith-Mahfouth N, et al. Cytogenetic monitoring of hospital staff exposed to ionizing radiation: Optimize protocol considering DNA repair genes variability. Int J Radiat Biol. 2017;93:1283-1288. Available from: https://doi.org/10.1080/09553002.2017.1377361.

Sakly A, Ayed Y, Chaari N, Akrout M, Bacha H, Cheikh HB. Assessment of chromosomal aberrations and micronuclei in peripheral lymphocytes from Tunisian hospital workers exposed to ionizing radiation. Genet Test Mol Biomarkers. 2013;17:650-655. Available from: https://doi.org/10.1089/gtmb.2012.0111.

Sakly A, Gaspar JF, Kerkeni E, Silva S, Teixeira JP, Chaari N, et al. Genotoxic damage in hospital workers exposed to ionizing radiation and metabolic gene polymorphisms. J Toxicol Environ Health A. 2012;75:934-946. Available from: https://doi.org/10.1080/15287394.2012.690710.

El-Benhawy SA, Sadek NA, Behery AK, Issa NM, Ali OK. Chromosomal aberrations and oxidative DNA adduct 8-hydroxy-2-deoxyguanosine as biomarkers of radiotoxicity in radiation workers. J Radiat Res Appl Sci. 2016;9:249-258. Available from: https://doi.org/10.1016/j.jrras.2015.12.004.

Miszczyk J, Gałaś A, Panek A, Kowalska A, Kostkiewicz M, Borkowska E, et al. Genotoxicity associated with ^131I and ^99mTc exposure in nuclear medicine staff: A physical and biological monitoring study. Cells. 2022;11(10):1655. Available from: https://doi.org/10.3390/cells11101655.

Saxe D, Seo EJ, Bergeron MB, Han JY. Recent advances in cytogenetic characterization of multiple myeloma. Int J Lab Hematol. 2019;41(1):5-14. Available from: https://doi.org/10.1111/ijlh.12882.

Gnanasekaran TS. Cytogenetic biological dosimetry assays: Recent developments and updates. Radiat Oncol J. 2021;39(3):159-166. Available from: https://doi.org/10.3857/roj.2021.00339.

Sommer S, Buraczewska I, Kruszewski M. Micronucleus assay: The state of art, and future directions. Int J Mol Sci. 2020;21(1534). Available from: https://doi.org/10.3390/ijms21041534.

Aguiar Torres L, dos Santos Rodrigues A, Linhares D, Camarinho R, Nunes Páscoa Soares Rego ZM, Ventura Garcia P. Buccal epithelial cell micronuclei: Sensitive, non-invasive biomarkers of occupational exposure to low doses of ionizing radiation. Mutat Res Genet Toxicol Environ Mutagen. 2019;838:54-58. Available from: https://doi.org/10.1016/j.mrgentox.2018.12.009.

Au WW, Badary OA, Heo MY. Cytogenetic assays for monitoring populations exposed to environmental mutagens. Occup Med. 2001;16(2):345-357. Available from: https://pubmed.ncbi.nlm.nih.gov/11319056/.

Siama Z, Zosang-Zuali M, Vanlalruati A, Jagetia GC, Pau KS, Kumar NS. Chronic low dose exposure of hospital workers to ionizing radiation leads to increased micronuclei frequency and reduced antioxidants in their peripheral blood lymphocytes. Int J Radiat Biol. 2019;95:697-709. Available from: https://doi.org/10.1080/09553002.2019.1571255

Guo L, Wu B, Wang X, Kou X, Zhu X, Fu K, et al. Long-term low-dose ionizing radiation induced chromosome-aberration-specific metabolic phenotype changes in radiation workers. J Pharm Biomed Anal. 2022;214:114718. Available from: https://doi.org/10.1016/j.jpba.2022.114718.

Shafiee M, Borzoueisileh S, Rashidfar R, Dehghan M, Jaafarian Sisakht Z. Chromosomal aberrations in C-arm fluoroscopy, CT-scan, lithotripsy, and digital radiology staff. Mutat Res. 2020;849:503131. Available from: https://doi.org/10.1016/j.mrgentox.2020.503131

International Atomic Energy Agency. Cytogenetic analysis for radiation dose assessment (Technical Reports Series No. 405). IAEA, Vienna; 2001. Available from: https://www.iaea.org/publications/6303/cytogenetic-analysis-for-radiation-dose-assessment.

Gao J, Dong X, Liu T, Zhang L, Ao L. Antioxidant status and cytogenetic damage in hospital workers occupationally exposed to low dose ionizing radiation. Mutat Res Genet Toxicol Environ Mutagen. 2020;850-851:503152. Available from: https://doi.org/10.1016/j.mrgentox.2020.503152

Scholten B, Vlaanderen J, Stierum R, Portengen L, Rothman N, Lan Q, et al. A quantitative meta-analysis of the relation between occupational benzene exposure and biomarkers of cytogenetic damage. Environ Health Perspect. 2020;128:87004. Available from: https://doi.org/10.1289/ehp6404

Lee KS, Choi YJ, Cho J, Lee H, Lee H, Park SJ, et al. Environmental and genetic risk factors of congenital anomalies: An umbrella review of systematic reviews and meta-analyses. J Korean Med Sci. 2021;36(28). Available from: https://doi.org/10.3346/jkms.2021.36.e183.

Virolainen SJ, VonHandorf A, Viel KCMF, Weirauch MT, Kottyan LC. Gene-environment interactions and their impact on human health. Genes Immun. 2023;24(1):1-11. Available from: https://doi.org/10.1038/s41435-022-00192-6.

Rosendahl Huber A, Van Hoeck A, Van Boxtel R. The Mutagenic Impact of Environmental Exposures in Human Cells and Cancer: Imprints Through Time. Front Genet. 2021;12:760039. Available from: https://doi.org/10.3389/fgene.2021.760039.

Yuan P, Zheng L, Ou S, Zhao H, Li R, Luo H, et al. Evaluation of chromosomal abnormalities from preimplantation genetic testing to the reproductive outcomes: A comparison between three different structural rearrangements based on next-generation sequencing. J Assist Reprod Genet. 2021;38(3):709-718. Available from: https://doi.org/10.1007/s10815-020-02053-5.

Garutti M, Foffano L, Mazzeo R, Michelotti A, Da Ros L, et al. Hereditary Cancer Syndromes: A Comprehensive Review with a Visual Tool. Genes. 2023;14(5):1025. Available from: https://doi.org/10.3390/genes14051025.

Benchikh S, Bousfiha A, Razoki L, Aboulfaraj J, Zarouf L, Elbakay C, et al. Chromosome abnormalities related to reproductive and sexual development disorders: A 5-year retrospective study. Biomed Res Int. 2021;2021:8893467. Available from: https://doi.org/10.1155/2021/8893467.

Benjamin RH, Nguyen JM, Canfield MA, Shumate CJ, Agopian AJ. Survival of neonates, infants, and children with birth defects: A population-based study in Texas, 1999-2018. Lancet Reg Health Am. 2023;27:100617. Available from: https://doi.org/10.1016/j.lana.2023.100617.

Canet M, Harbron R, Thierry-Chef I, Cardis E. Cancer effects of low to moderate doses of ionizing radiation in young people with cancer-predisposing conditions: A systematic review. Cancer Epidemiol Biomarkers Prev. 2022;31(10):1871-1889. Available from: https://doi.org/10.1158/1055-9965.EPI-22-0393.